| umls-concept:C0008168 | skos:definition | MSH: An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106),CSP: antibiotic first isolated from cultures of Streptomyces venequelae but now produced synthetically; has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered; it acts by interfering with bacterial protein synthesis and is mainly bacteriostatic.,NCI: A semisynthetic, broad-spectrum antibiotic derived from Streptomyces venequelae with primarily bacteriostatic activity. Chloramphenicol diffuses through the bacterial cell wall and reversibly binds to the bacterial 50S ribosomal subunit. The binding interferes with peptidyl transferase activity, thereby prevents transfer of amino acids to the growing peptide chains and blo | lld:umls |
