| umls-concept:C0002895 | skos:definition | MSH: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.,CSP: disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs; the clinical expression of homozygosity for hemoglobin S.,MEDLINEPLUS: <p>Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. The cells are shaped like a crescent or sickle. They don't last as long as normal, round red blood cells, which leads to <a href='http://www.nlm.nih.gov/medlineplus/anemia.html'>anemia</a>. The sickle cells also get stuck in blood vessels, blocking blood flow. This can cause pain and organ damage.</p> <p>A genetic problem causes sickle cell anemia. People with the disease are born with two sickle cell genes, one from each parent. If you only have one sickle cell gene, it's called sickle cell trait. About 1 in 12 African Americans has s | lld:umls |
