| umls-concept:C0001899 | skos:definition | MSH: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.,NCI: Expressed in liver, kidney, heart, fat, and skeletal muscle by glucocorticoid-induced human GPT Gene (Alanine Aminotransferase Family), 495-aa 54-kDa Glutamic-Pyruvate Transaminase is a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. GPT mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI) | lld:umls |
