Source:http://linkedlifedata.com/resource/umls/id/C1831828
PDQ: An oncolytic, recombinant herpes simplex type-1 virus (HSV) encoding thuman cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antitumor and immunostimulating properties. Upon administration, GM-CSF-encoding oncolytic HSV selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis. In addition, expressed GM-CSF may stimulate a cytotoxic T cell response against tumor cells, resulting in immune-mediated tumor cell death in addition to HSV-mediated oncolytic tumor cell death. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=485296&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=485296&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C61314" NCI Thesaurus),NCI: An oncolytic, recombinant herpes simplex type-1 virus (HSV) encoding human cytokine granulocyte-macrophage colony stimulating facto