Source:http://linkedlifedata.com/resource/umls/id/C1744635
MSH: A subcategory of phospholipases A2 that occur in the CYTOSOL.,NCI: Expressed in macrophages, platelets, neutrophils, fibroblasts, and lung endothelia by human PLA2G4A Gene, Cytosolic Phospholipase A2G4A is activated by serine phosphorylation and translocated to the membrane in a calcium-dependent fashion. The N-terminal lipid membrane-associated C2 domain regulates PLA2G4A by presenting the active site to substrates in response to cytosolic Ca(2+) elevation. PLA2G4A interacts with HTATIP and is stimulated by ATP, EGF, thrombin, and bradykinin. PLA2G4A selectively hydrolyzes ubiquitous membrane (sn-2) arachidonyl phospholipids releasing the 20-carbon arachidonic acid precursor for many eicosanoid effectors involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Eicosanoid lipids include prostaglandins, thromboxanes, leukotrienes, hydroxy- and epoxy-fatty acids, lipoxins, and isoprostanes. (NCI)