| Subject | Predicate | Object | Context |
|---|---|---|---|
| umls-concept:C1709429 | rdf:type | umls-semnetwork:T116 | lld:umls |
| umls-concept:C1709429 | rdf:type | umls-semnetwork:T121 | lld:umls |
| umls-concept:C1709429 | rdf:type | skos:Concept | lld:umls |
| umls-concept:C1709429 | calbc:hasCorrelation | calbc-group:CHEM | lld:calbc |
| umls-concept:C1709429 | skos:definition | PDQ: An epoxomicin derivate with potential antineoplastic activity. PR-171 irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459751&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=459751&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C52196" NCI Thesaurus) | lld:umls |
| umls-concept:C1709429 | skos:inScheme | lld:umls | lld:umls |
| umls-concept:C1709429 | skos-xl:prefLabel | umls-label:A12093152 | lld:umls |
| umls-concept:C1709429 | skos-xl:altLabel | umls-label:A11918702 | lld:umls |
| umls-concept:C0028954 | skos:narrower | umls-concept:C1709429 | lld:umls |
| pubmed-article:17341267 | lifeskim:mentions | umls-concept:C1709429 | lld:lifeskim |
| pubmed-article:17616698 | lifeskim:mentions | umls-concept:C1709429 | lld:lifeskim |
| pubmed-article:19903785 | lifeskim:mentions | umls-concept:C1709429 | lld:lifeskim |
| http://linkedlifedata.com/r... | umls:relatedConcept | umls-concept:C1709429 | lld:umls |