PAX3-FOXO1 Fusion Protein

Source:http://linkedlifedata.com/resource/umls/id/C1709387

NCI: A fusion protein consisting of the intact paired box protein Pax-3 N-terminal DNA binding domain fused in-framed to the intact forkhead box protein O1 C-terminal transcriptional activation domain. This gene product is associated with aberrant transcriptional activation and alveolar rhabdomyosarcoma. (Atlas of Genetics and Cytogenetics in Oncology and Haematology),NCI: A fusion protein (836 aa, ~92 kDa) encoded by the PAX3/FOXO1 fusion gene. This protein is comprised of the N-terminal DNA binding domain of paired box protein Pax-3 and the C-terminal transactivation domain of forkhead box protein O1.

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