Source:http://linkedlifedata.com/resource/umls/id/C1519143
NCI: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called DNA cross-linking agents.,NCI: A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. (NCI05),PDQ: A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=415963&idtype=1