Source:http://linkedlifedata.com/resource/umls/id/C1512583
NCI: Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events.