Source:http://linkedlifedata.com/resource/umls/id/C1453171
NCI: Caspase-2, encoded by the CASP2 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)