Source:http://linkedlifedata.com/resource/umls/id/C1447487
NCI: Highly expressed in testis and spleen by human RAD54B Gene (SNF2/SWI2 Family), the two isoforms of 910-aa 100-kD nucleoplasmic RAD54B Homolog exhibit significant homology to RAD54 and motifs similar to DNA and RNA helicases. RAD54B binds to double-stranded DNA and displays DNA-associated ATPase activity. RAD54B appears to associate indirectly with RAD51 through its N-terminal domain and may colocalize with RAD54 and BRCA1. Part of a complex involved in meiotic and mitotic homologous DNA recombination repair, RAD54B plays a critical role in targeted integration and recombination in concert with other RAD52 epistasis group members without affecting cell growth, sensitivity to DNA damaging agents, or sister chromatid exchange. (NCI)