| umls-concept:C1384543 | skos:definition | NCI: Expressed predominantly in hematopoietic cells by human PTPN6 Gene (Non-Receptor PTP Family), 3 distinct alternative isoforms of cytoplasmic serine/tyrosine phosphorylated Non-Receptor Type 6 Protein Tyrosine Phosphatase contain two tandem N-terminal phosphotyrosine binding SH2 domains that mediate interaction with substrates and may modulate phosphatase activity through interaction with other cellular components. A key regulator of hematopoiesis, PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways. PTPN6 binds to PTPNS1, LILRB1, and LILRB2. Protein Tyrosine Phosphatases typically regulate cell growth, differentiation, and mitotic cycle. (NCI) | lld:umls |
