Source:http://linkedlifedata.com/resource/umls/id/C1364684
NCI: Cytokine-Inducible Kinase, encoded by the human CNK gene, is a serine/threonine protein kinase that is involved in regulating M phase functions during the cell cycle. This membrane-associated protein may play a role in regulation of cell cycle progression and tumorigenesis. It may also be part of the signaling network controlling cellular adhesion. It is phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Cytokine and cellular adhesion trigger CNK induction. CNK contains both a catalytic domain and a putative regulatory domain. It binds to the calcium/integrin-binding protein (CIB) and this interaction probably occurs via the polo-box domain. Transcripts expression appears to be down-regulated in primary lung tumor. (From LocusLink, Swiss-Prot and NCI)