Source:http://linkedlifedata.com/resource/umls/id/C1336641
NCI: A fusion gene that results from a genetic translocation event which fuses the 5' end of the androgen-regulated TMPRRSS2 gene with the entire coding region of the ERG gene. The androgen-dependent expression of this fusion gene results in overexpression of ERG activity.,NCI: A fusion gene that results from a chromosomal translocation t(7;21)(p21;q22) which fuses the 5' end of the TMPRRSS2 gene with exon 4 of the ETV1 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 1 protein activity.,NCI: This gene plays a role in the activation of pathway signaling.