Source:http://linkedlifedata.com/resource/umls/id/C1335137
NCI: Abundantly expressed in spleen, ovary, testes, colon mucosa, and prostate, human ORC5L Gene (ORC5 Family) encodes 435-aa 50-kDa nuclear Origin Recognition Complex Subunit 5, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. While ORC5 forms a core ORC complex with ORC2L, -3L, and -4L, the ORC5T isoform interacts with ORC4L, but not ORC2L, and regulates assembly of different ORC subcomplexes. ORC5 has a role in transcriptional silencing. (NCI)