Source:http://linkedlifedata.com/resource/umls/id/C1332360
NCI: Encoded by human AXIN2 Gene, ubiquitous cytoplasmic Conductin may inhibit the WNT pathway by regulating beta-catenin stability. AXIN2 contains DIX, RGS-signaling, GSK-binding, beta-catenin-binding, and DSH domains. Mouse conductin organizes an APC/beta-catenin/GSK3B complex that promotes beta-catenin degradation. Conductin may facilitate phosphorylation of APC and beta-catenin by GSK3B. Armadillo repeats mediate interaction with beta-catenin. GSK3B may phosphorylate AXIN2, likely dephosphorylated by PP2A. Colorectal cancer associated with MMR gene alterations result in AXIN2 mutations, stabilization of beta-catenin, and activation of beta-catenin/TCF signaling. (from SWISS-PROT, OMIM, Proteome, and NCI),NCI: Axin 2 protein is presumed to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, gly