EXTL2 protein, human

Source:http://linkedlifedata.com/resource/umls/id/C1308415

NCI: Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)

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