core-binding factor complex

Source:http://linkedlifedata.com/resource/umls/id/C1167132

GO: A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. [PMID:15156179, PMID:8497254]

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