| umls-concept:C1158727 | skos:definition | NCI: Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic export, and translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA is an important process conserved from bacteria to humans. In eukaryotes, polyadenylation is essential for the stability of many mRNAs and also influences the efficiency of translation. Most histone-mRNAs and all snRNAs (except U6), however are not polyadenylated. The mature mRNA moves to the nuclear surface and is exported through nuclear pores.,GO: The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. [ISBN:0198506732] | lld:umls |
