| umls-concept:C1142934 | skos:definition | NCI: A substance being studied in the treatment of prostate and other types of cancer. It contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.,PDQ: An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42141&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42141&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1493" NCI Thesaurus),NCI: An orally administered third generation platinum compound with potential ant | lld:umls |
