| umls-concept:C0966748 | skos:definition | NCI: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors.,PDQ: A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256405&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=256405&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2801" NCI Thesaurus),NCI: A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcript | lld:umls |
