Fanconi Anemia Complementation Group D2 Protein

Source:http://linkedlifedata.com/resource/umls/id/C0965234

NCI: Fanconi anemia group D2 protein (1471 aa, ~166 kDa) is encoded by the human FANCD2 gene. This protein plays a role in chromosome pairing during meiosis, repair of DNA double-strand breaks and cell cycle checkpoint regulation.,MSH: A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.

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