Source:http://linkedlifedata.com/resource/umls/id/C0908506
MSH: A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.,NCI: The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. They are implicated in mediating developmental events, particularly in the nervous system. They typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. Their ligands are called ephrins. Based on structure and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, and the ephrin-B (EFNB) class. The Eph family of receptors are divided into 2 groups based on t