Source:http://linkedlifedata.com/resource/umls/id/C0812211
NCI: This gene is involved in signal transduction.,NCI: Human Oncogene MCF2 is a mutated variant of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. Oncogene MCF2 disrupts normal cell function.,NCI: Human oncogene DBL is a mutated form of the MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, which encodes 4 alternative variants of the proto-oncogene DBL protein. Activation of the DBL oncogene is generated by 5-prime recombination with chromosome 3pter-p21 and by 3-prim