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| umls-concept:C0771055 | calbc:hasCorrelation | calbc-group:CHEM | lld:calbc |
| umls-concept:C0771055 | skos:definition | NCI: A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death. | lld:umls |
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