Source:http://linkedlifedata.com/resource/umls/id/C0771019
NCI: A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).,PDQ: The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42793&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42793&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov: