Source:http://linkedlifedata.com/resource/umls/id/C0758959
MSH: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.,NCI: Caspase-10, encoded by the CASP10 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-10 is involved in the activation cascade of caspases responsible for apoptosis execution. It is recruited to both FAS- and TNFR-1 receptors in a FADD dependent manner. Caspase-10 cleaves and a