A Kinase Anchor Protein 9

Source:http://linkedlifedata.com/resource/umls/id/C0672770

NCI: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. (from LocusLink),NCI: Encoded by human AKAP9 Gene, 3911-amino acid 454 kD A Kinase Anchor Protein 9 is widely expressed as alternative isoforms: 1, 2, 3/CG-NAP, 4/Yotiao, 5, and 6/AKAP350. Full-length protein contains many coiled-coil regions. Centrosomal, cytoskeletal, cytoplasmic, or associated with postsynaptic densitie

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