| umls-concept:C0667830 | skos:definition | MSH: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.,NCI: A member of the ICE cysteine-protease family. A downstream factor in apoptosis induced by TNFR and FAS,NCI: A protease cascade, involving ICE/CED-3 family aspartate-specific cysteine proteases, is responsible for apoptotic programmed cell death. FLICE is a downstream factor in TNFR- and FAS-induced apoptosis and forms an active protease after pro-enzyme cleavage into two subunits that dimerize to form active enzyme. FLICE contains FADD-like domains, suggesting a possible interaction with FADD. (from OMIM 603599 and NCI) | lld:umls |
