Source:http://linkedlifedata.com/resource/umls/id/C0540587
NCI: Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI),NCI: Neuregulin-2, a novel neuregulin-1-like molecule encoded by a distinct gene. Like neuregulin-1, neuregulin-2 also binds to ErbB3 an