Source:http://linkedlifedata.com/resource/umls/id/C0388246
NCI: The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8),NCI: WRN protein (1432 amino acids) functions as a 3-5 DNA helicase and a 3-5 exonuclease. It interacts with DNA polymerase delta (POLD1) and RPA which are required for DNA replication and DNA repair, with Ku which is involved in double strand DNA break repair by non-homologous DNA end joining, and with p53. It contains one ATP binding site, one DExH helicase box, one exonuclease domain unique among known RecQ helicases in the N-terminal region, a nuclear localization signal in the C-terminus and a direct repeat of 27