Source:http://linkedlifedata.com/resource/umls/id/C0385939
NCI: The SMAD4 tumor suppressor protein specifically recognizes an eight base pair palindromic DNA sequence and is critical for transmitting TGFB, and related cytokine signals, to the cell nucleus to mediate transcriptional activation of target genes. The MADH4 gene is a cloned gene for Juvenile Polyposis, associated with colon cancer. (from OMIM 600993 and NCI)