Source:http://linkedlifedata.com/resource/umls/id/C0378212
MSH: A guanine nucleotide exchange factor that stimulates the dissociation of GDP from RAL GTP-BINDING PROTEINS. It also has GDP exchange activity towards other MONOMERIC GTP-BINDING PROTEINS.,NCI: Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N-terminal RAS-GEF domain and a noncatalytic C-terminal RAS-associating domain. RALGDS interaction as an effector molecule with RAS-like molecules is specific and dependent on RAS activation by GTP. RALGDS stimulates dissociation of GDP from RAS-related RALA and RALB GTPases, allowing GTP binding and GTPase activation. (NCI)