Source:http://linkedlifedata.com/resource/umls/id/C0282579
MSH: A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed),CSP: test for the presence and specificity of DNA binding proteins and their binding sites on DNA, based on their tendency to prevent DNA cleavage by restriction enzymes.,NCI: A procedure that determines the sequence specificity for DNA binding proteins. Target DNA is end-labeled and exposed to the protein of interest. The sample is then treated with a DNA damaging agent that cleaves at random base pairs. Protein-bound DNA is protected from the cleavage and can be analyzed by gel electrophoresis.