Source:http://linkedlifedata.com/resource/umls/id/C0255873
MSH: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.,NCI: Encoded by human PTPN12 Gene (Non-Receptor PTP Family), 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase contains a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 ar