Source:http://linkedlifedata.com/resource/umls/id/C0243036
MSH: Retrovirus-associated DNA sequences (erbB) originally isolated from, or related to, the avian erythroblastosis virus (AEV). These genes code for the epidermal growth factor receptor (EGFR) family of receptors which is important in the control of normal cell proliferation and in the pathogenesis of human cancer. The genes include erbB-1 (GENES, ERBB-1), erbB-2 (GENES, ERBB-2), and erbB-3, all of which show abnormalities of expression in various human neoplasms.,NCI: ERBB DNA sequences are related to certain avian erythroblastosis virus sequences. The cellular genes encode members of the epidermal growth factor receptor (EGFR) family (ERBB1, 2, 3, and 4). The 110-kb EGFR gene locus encodes the EGF receptor, a cell surface transmembrane protein tyrosine kinase involved in regulation of cell growth and differentiation. ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptor tyrosine kinase homo- and heterodimers important in the control of cell proliferation and in the pathogenesis of human cancer