Source:http://linkedlifedata.com/resource/umls/id/C0213800
NCI: An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.,PDQ: A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42528&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42528&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1485" NCI Thesaurus)