Statements in which the resource exists.
SubjectPredicateObjectContext
umls-concept:C0210994rdf:typeumls-semnetwork:T116lld:umls
umls-concept:C0210994rdf:typeumls-semnetwork:T123lld:umls
umls-concept:C0210994rdf:typeskos:Conceptlld:umls
umls-concept:C0210994calbc:hasCorrelationcalbc-group:LIVBlld:calbc
umls-concept:C0210994calbc:hasCorrelationcalbc-group:DISOlld:calbc
umls-concept:C0210994calbc:hasCorrelationcalbc-group:GENElld:calbc
umls-concept:C0210994calbc:hasCorrelationcalbc-group:PHYSlld:calbc
umls-concept:C0210994calbc:hasCorrelationcalbc-group:CHEMlld:calbc
umls-concept:C0210994skos:definitionNCI: DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)lld:umls
umls-concept:C0210994skos:inSchemelld:umlslld:umls
umls-concept:C0210994skos-xl:prefLabelumls-label:A1961727lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7608757lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7587407lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7593268lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7592677lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7592865lld:umls
umls-concept:C0210994skos-xl:altLabelumls-label:A7604785lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
umls-concept:C0210994umls:relationhttp://linkedlifedata.com/r...lld:umls
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