| umls-concept:C0146403 | skos:definition | NCI: A polycyclic aromatic hydrocarbon and metabolite of benzo(a)pyrene with potent cytotoxic and mutagenic properties. Benzo(a)pyrene-trans-7,8-dihydrodiol is an intermediate in the conversion of benzo(a)pyrene to the highly potent mutagen and carcinogen benzopyrene diol epoxide via cytochrome P450 CYP1A1. | lld:umls |
