Source:http://linkedlifedata.com/resource/umls/id/C0121258
MSH: An eph family receptor that is found primarily in adult BRAIN and variety of tissues in the developing embryo tissues. During embryonic development high levels of EphA3 receptor expression is seen in the nervous system and coincides with neuronal cell migration, suggesting a role for this protein in axonal pathfinding.,NCI: The HEK receptor tyrosine kinase shows a high degree of homology with EPH and ELK RTKs. The largest subfamily of RTKs, EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). HEK expression appears restricted to lymphoid tumor cell lines, suggesting that HEK may contribute to lymphoid malignancies and normal lymphoid function and