Source:http://linkedlifedata.com/resource/umls/id/C0106158
NCI: Encoded by human TGFBR3 Gene, 849-aa 93-kDa (precursor) Transforming Growth Factor Beta Receptor III is a membrane-bound or soluble glycoprotein heavily modified by glycosaminoglycan groups, with regions of similarity to endoglin, and containing a ZP domain. Lacking a recognizable signaling domain, TGFBR3 binds to TGF-Beta and may be a TGFBR and FGFR receptor accessory molecule; it may capture and retain TGF-Beta for presentation to signaling receptors. TGF-beta is a multifunctional cytokine that modulates cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. TGFBR3 can also bind inhibin and function as coreceptor with ActRII; inhibin forms crosslinked complexes with TGFBR3 and ActRII. TGFBR3 also binds beta arrestin 2, which appears to trigger cytoplasmic phosphorylation by TGFBR2. (NCI)