| umls-concept:C0081181 | skos:definition | NCI: An anticancer drug that is a type of angiogenesis inhibitor.,PDQ: A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Dimethylxanthenone acetic acid induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43320&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43320&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2504" NCI Thesaurus) | lld:umls |
