Mutagenesis, Insertional

Source:http://linkedlifedata.com/resource/umls/id/C0079868

MSH: Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.,NCI: Mutagenesis of DNA by the insertion of one or more bases.

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