Glutamate Carboxypeptidase II

Source:http://linkedlifedata.com/resource/umls/id/C0067685

MSH: A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.,NCI: Prostate-specific membrane antigen (PSMA) is an integral membrane protein that is highly expressed on the surface of prostate epithelial cells and tumor-associated vascular endothelia. It is also expressed on the vascular endothelium of a number of tumor types. PSMA gene has been cloned through detection with a monoclonal antibody raised against the human prostatic carcinoma cell line LNCaP. Subsequently, PSMA gene was shown to be identical to glutamate carboxypepidase II (GCP2) gene, and to encode a type II transmembrane protein with folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALAdase) activity. (from OMIM),NCI: A transmembrane glycoprotein present in tumor-associated vasculature but not associated with normal or benign tissue. P

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