| umls-concept:C0051066 | skos:definition | NCI: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites.,PDQ: An amino acid analog derived from Streptomyces alanosinicus, a purine antagonist, and an adenylosuccinate synthetase inhibitor with antineoplastic properties. L-alanosine deprives MTAP-deficient (salvage pathway) tumor cells of de novo synthesized adenosine and is probably responsible for diminished DNA synthesis. The clinical use of L-alanosine may be narrow due to its toxicity profile. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39138&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39138&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C994" NCI Thesaurus),NCI: An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L | lld:umls |
