| umls-concept:C0039195 | skos:definition | MSH: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.,CSP: antibody-independent "killer cells" derived from the CD8 T lymphocyte line which, when stimulated by antigen, MHC class I antigen, and interleukin 2, secrete cytolytic pore-forming proteins capable of lysing target cells.,NCI: A type of immune cell that can kill certain cells, including foreign cells, cancer cells, and cells infected with a virus. Cytotoxic T lymphocytes can be separated from other blood cells, grown in the laboratory, and then given to a pat | lld:umls |
