| umls-concept:C0034818 | skos:definition | MSH: A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.,CSP: a tyrosine kinase type, transmembrane receptor, which places it in the growth factor receptor family, even though insulin is usually considered a hormone.,NCI: Insulin receptor (1382 aa, ~156 kDa) is encoded by the human INSR gene. This protein plays a role in both signal transduction and glucose homeostasis. | lld:umls |
