| umls-concept:C0033218 | skos:definition | MSH: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).,CSP: local anesthetic of the ester type that has a slow onset and a short duration of action, mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.,NCI: A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation. | lld:umls |
