| umls-concept:C0021755 | skos:definition | MSH: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.,CSP: macrophage produced interleukin that induces the production of interleukin 2 by T cells that have been stimulated by antigen or mitogen; at least two types, alpha and beta, exist; interleukin 1 or a similar protein is also produced by epithelial cells and stimulates fibroblast proliferation and release of proteolytic enzymes and prostaglandins in inflammatory processes.,NCI: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-1 is made mainly by one type of white blood cell, the macrophage, and helps another type of white blood cell, the lymphocyte, fight infections. I | lld:umls |
