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| umls-concept:C0018873 | skos:definition | CSP: first continuously cultured human malignant cell line, derived from a cervical carcinoma; used for virus cultivation and antitumor drug screening assays.,MSH: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.,NCI: HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences. P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported. M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5. M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chro | lld:umls |
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